Project Summary / Abstract: This application is a proposal for a Fellowship training program in pediatric endocrinology, designed to provide multidisciplinary training in diabetes research at The Barbara Davis Center (BDC), and the Children’s Hospital Colorado (CHC) at the University of Colorado Anschutz Medical Campus (CU AMC). It also proposes to train post-doctoral psychologists in diabetes behavioral research. Funding is requested for two years of research training for three Pediatric Endocrinology trainees and one PhD psychologist in each year of the Program as well as 3 Summer Medical Students (Short-term Scholars Program). The proposal’s rationale is: 1) There is a critical shortage of pediatric endocrinologists and psychologists trained in diabetes research 2) Diabetes is an increasingly significant healthcare problem in the pediatric population with devastating consequences from a personal and health economics viewpoint 3) Current rapid advances in diabetes investigation calls for an increased pool of physician scientists trained in clinical, biochemical, epidemiological, and behavioral research to carry out basic and translational research in pediatric type 1 (T1D) and type 2 diabetes (T2D) to bring advances in diabetes research to the clinical arena. Psychologists training in behavioral research beside physicians will add strength to the physician program and contribute diabetes research trained psychologists to the very small pool of these important specialists. The BDC and CHC have an extensive and proven record in research training of young investigators. A strong endocrinology program at CHC, in addition to a research program in T2D, will provide a well-rounded pediatric endocrinology training program. The BDC, CHC and the wider CU AMC have well-established investigators in the epidemiology, pathophysiology, immunobiology, genetics, and molecular biology of T1D and T2D. This network of experienced mentors is ideally suited to develop the next generation of young pediatric endocrinologists prepared for a career as diabetes investigators. Areas of research focus within the BDC include developmental islet cell biology, genetics, immunology, autoimmunity, prediction and prevention of T1D, as well as the epidemiology of and novel treatments for T1D and T2D. The integration of psychologists training in diabetes behavioral research will add importance and depth to the Program. These areas of research are urgently needed and have been identified as important to the national public health to address diabetes in the US. This application is enhanced and supported by Colorado Clinical and Translational Research Institute, the Pediatric Clinical Translational Research Center, the CU Diabetes Research Center, the Departments of Pediatrics, Medicine and the Colorado School of Public Health. The ability to provide strong didactic courses in statistics, epidemiology, research methods, ethics and regulation of human research, medical writing, molecu...