Abstract On behalf of the ACE network, the Emory ACE Fund Management Core (EAFMC) at Emory University proposes to continue to manage two funds. The first will be the Clinical Project Fund, which will support all of the Clinical Projects (ClinProj) within the ACE. The second will be the Collaborative Research Fund (CRF). The CRF will provide funding support for the Collaborative Projects of the ACE, as well as additional studies that are added for achieving the ACE research agenda. It is estimated from the RFA that the AFMC will manage $3.2M in direct costs associated with these projects and that these will occur through about 100 consortium agreements emanating from up to 50 different sites. It will accomplish this through the following aims: (1) Continue to enhance the administration and management of the clinical and collaborative projects; (2) Streamline the development of budgets and consortium agreements; (3) Establish templates for the CliniPrj and CRP budget agreements; (4) Implement procedures to pay invoices and resolve problems and (5) Develop procedures for accountability, communication and reporting to the ACE Steering Committee and NIAID; all by utilizing the (6) EAFMC Templates developed.