# Transgenic Mouse Facility

> **NIH NIH P30** · UNIVERSITY OF CHICAGO · 2024 · $196,364

## Abstract

PROJECT SUMMARY/ABSTRACT - TRANSGENIC MOUSE FACILITY (TMF)
The University of Chicago Medicine Comprehensive Cancer Center (UCCCC) Transgenic Mouse Facility
(TMF) supports the development of state-of-the-art mouse models of cancer for University of Chicago
Medicine Comprehensive Cancer Center (UCCCC) investigators. The TMF’s major objective is to provide
high quality, cost-effective, custom services related to genetically engineered mouse models (GEMMs)
tailored to the needs of individual researcher. TMF supports the scientific needs of UCCCC investigators
related to the generation, breeding and maintenance of genetically engineered mice. In the reporting period,
19 unique UCCCC members (63% MMC, 37% IC) utilized TMF for their research. In addition, 31 cancer-
related federal grants, and 30 cancer relevant peer reviewed publications (37% in journals with impact factor
> 10) resulted from research involving the TMF. The TMF allows investigators to maintain intellectual
ownership of the models generated, an advantage over commercial services. Future efforts are aimed at
maintaining the high-quality services offered. TMF anticipates increasing usage through increasing demand
for animals with patient specific mutations in the next CCSG cycle. To meet the demand, TMF will continue
to evaluate rapidly evolving gene editing technologies for efficiency and application to animal model
development and ensure that staff are trained in new approaches both on-site and through participating in
external workshops.

## Key facts

- **NIH application ID:** 10845113
- **Project number:** 2P30CA014599-48
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **Principal Investigator:** KAY F MACLEOD
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $196,364
- **Award type:** 2
- **Project period:** 1997-09-01 → 2029-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10845113

## Citation

> US National Institutes of Health, RePORTER application 10845113, Transgenic Mouse Facility (2P30CA014599-48). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10845113. Licensed CC0.

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