# Whole Eye Optical Coherence Tomography to Improve Eye Care

> **NIH NIH R01** · DUKE UNIVERSITY · 2024 · $400,059

## Abstract

ABSTRACT
This research proposal from a multi-disciplinary team including ophthalmologists and biomedical engineers
seeks to improve the imaging and characterization of posterior eye deformities such as in progressive or
pathologic myopic and high intracranial pressure. The three-dimensional changes seen in the posterior eye
with these diseases have usually been characterized using neuro-imaging. To make this assessment more
available in the clinical ophthalmic setting, we will further develop our “whole eye” optical coherence
tomography (OCT) system specifically for this application. This OCT system will have hardware and software
innovations to quantitatively assess the three-dimensional deformation of the posterior eye in these diseases.
With these data, we can identify shape metrics which can help to distinguish pathologic from “regular” high
myopia, progressive from non-progressive myopia, and for high intracranial pressure, we will assess the
evolution of the eye deformation in the posterior eye over the patient’s care.
These developments have both direct immediate clinical and research applicability by providing imaging
biomarkers to characterize posterior eye deformation. In addition, given that a whole eye OCT system will be
deployed to a second site, there will be a demonstration of the applicability of this technology outside the origin
laboratory.

## Key facts

- **NIH application ID:** 10845488
- **Project number:** 5R01EY024312-09
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Anthony Nanlin Kuo
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $400,059
- **Award type:** 5
- **Project period:** 2014-12-01 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10845488

## Citation

> US National Institutes of Health, RePORTER application 10845488, Whole Eye Optical Coherence Tomography to Improve Eye Care (5R01EY024312-09). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10845488. Licensed CC0.

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