PROJECT SUMMARY/ABSTRACT The Human Immunology Project Consortium (HIPC) was founded in 2010 to create a network of independent centers focused on measuring human immune responses with high-throughput systems immunology approaches coupled with detailed clinical phenotyping. We propose to develop a HIPC Coordinating Center (HCC) that will provide data more rapidly and effectively to the broader scientific community, and also serve the entire HIPC by increasing the value of the research performed at HIPC Centers. In parallel, the HCC will serve as a promoter of cross-HIPC collaborations through the organization of multi-center analysis projects and a centralized Portal to provide a space for the exchange of ideas. Specifically, the HCC will continue the development of shared data standards, provide a central Knowledgebase of study results, establish tools to visualize and analyze data, lead synergistic cross-center analysis efforts, provide a Portal to make the tools and data broadly accessible, and provide administrative support for the activities of HIPC subcommittees and management of the Infrastructure and Opportunity Fund (IOF) program. Our team has proven experience in running programs of similar scale and complexity. We also have the necessary familiarity with the HIPC network, with our team including current PIs of the Data Standards IOF project, the Signatures IOF project, clinical information capture, and the existing ImmuneSpace data portal. This proposal leverages this combined experience and infrastructure while, in parallel, implementing various significant and necessary improvements facilitated by the tighter integration and the 5-year time horizon of this dedicated HCC grant.