# Regional Metabolomics and Fluxomics Core at Princeton

> **NIH NIH P30** · UNIVERSITY OF PENNSYLVANIA · 2024 · $250,095

## Abstract

SUMMARY
The DRC Regional Metabolomics and Fluxomics Core at Princeton provides Penn DRC investigators with
access to state-of-the-art metabolomics and flux analysis. These capabilities allow DRC investigators to
measure, both broadly and quantitatively, metabolic activity in cell culture, animal model, and clinical
specimens relevant to diabetes and obesity. Usage is high, at about 5000 samples annually. Scientific impact
has also been high, with 34 DRC publications as a Primary Core, including Cell, Science, Nature x 2, Journal
of Clinical Investigation x 2, Nature Metabolism x 3, and Cell Metabolism x 7. This impact reflects the
intellectual synergies between the Core’s expertise in quantitative metabolomics and isotope tracing and DRC
member expertise in diabetes and obesity. In the coming five years, the Core will continue to provide world-class
Metabolomics and Lipodomics measurements with and without isotope labeling. It will also continue to assist
Users with experimental design and data interpretation and to advance methods to meet User needs. In addition,
the Core will introduce new capacity in Spatial Metabolomics and Fluxomics based on MALDI imaging mass
spectrometry. The goal is to enable Users to make measurements of key diabetes-relevant metabolites and
fluxes in tissue slices with single-cell spatial resolution. Access to these capabilities will both accelerate and
expand the horizons of DRC science, leading to improved diagnosis and treatment of diabetes, obesity, and
related disorders.

## Key facts

- **NIH application ID:** 10845598
- **Project number:** 5P30DK019525-48
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** JOSHUA D RABINOWITZ
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $250,095
- **Award type:** 5
- **Project period:** 1997-03-01 → 2027-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10845598

## Citation

> US National Institutes of Health, RePORTER application 10845598, Regional Metabolomics and Fluxomics Core at Princeton (5P30DK019525-48). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10845598. Licensed CC0.

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