# DP22-002 Epidemiology of Lupus: Longitudinal Studies in Population-Based Cohorts - 2022

> **NIH ALLCDC U01** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $950,000

## Abstract

PROJECT SUMMARY
Systemic Lupus Erythematosus is a systemic autoimmune condition which is life long and can be life threatening.
Up to 15-20% of all SLE patients are diagnosed in childhood (<18 years of age). Although it is estimated that up
to 10,000 children in the United States have pediatric-onset SLE (pSLE), the natural history, treatment and
outcomes for this vulnerable population of children have not been well defined.
We propose to use the well-established Childhood Arthritis and Rheumatology Research Alliance (CARRA)
pSLE registry, which currently includes 870 patients followed longitudinally for up to ten years (goal of enrolling
1300-1400 participants), in order to thoroughly assess the biologic/disease related factors, as well as the non-
biologic factors, which can impact short and long-term pSLE outcomes. This proposal will address critical gaps
in pSLE knowledge including description of treatments for lupus nephritis and the prevalence and outcomes of
neuropsychiatric pSLE, the two primary causes of pSLE short and long-term morbidity. In addition, we will
describe important patient reported outcomes including pain, quality of life and disability, and long-term
outcomes, including transition to adulthood.
Research findings will be disseminated through patient/family partnerships with a goal of developing future
interventions to improve the health and well- being of patients with pSLE.

## Key facts

- **NIH application ID:** 10846547
- **Project number:** 5U01DP006702-03
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** Aimee O Hersh
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** ALLCDC
- **Fiscal year:** 2024
- **Award amount:** $950,000
- **Award type:** 5
- **Project period:** 2022-09-30 → 2027-09-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10846547

## Citation

> US National Institutes of Health, RePORTER application 10846547, DP22-002 Epidemiology of Lupus: Longitudinal Studies in Population-Based Cohorts - 2022 (5U01DP006702-03). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10846547. Licensed CC0.

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