Project Summary The University of Washington training program in Addiction Neuroscience is designed to provide a cohesive training environment for six predoctoral and four postdoctoral fellows per year, interested in the molecular, cellular and behavioral aspects of opioid, cannabinoid, and psychostimulant drug actions and their associated behaviors. The program emphasizes training in research skills along with career development professional skills and responsible conduct of research-ethical skills. Faculty mentors provide training in a broad range of research approaches including molecular pharmacology, electrophysiology, neurochemistry, neuroinflammation, mouse genetics, viral-based gene expression, optogenetics, chemogenetics and behavioral pharmacology. In addition to the general, ongoing training typical at this vibrant institution, trainees in this program experience a coordinated series of events specifically designed for their benefit including invited speaker seminar sessions featuring internationally respected drug abuse researchers; regular research progress meetings featuring local experts in addictive drug research; weekly journal clubs on the current literature of opioid, cannabinoid and psychostimulant research; frequent opportunities for the trainees to enhance their presentation skills; courses organized for them on the 'Molecular Basis of Addiction', 'Neural Circuits Underlying Motivated Behavior and Addiction' and 'Addiction: Mechanisms, Treatment, Prevention'; and career development seminars designed to strengthen their scientific and professional foundations. Faculty mentors are highly collaborative, and trainees benefit from a strongly interactive, multidisciplinary research program. The training program will continue to be a catalyst for research collaborations among the participating labs, for technology transfer between labs, and for collaborative NIDA-research grants. The trainees are drawn from an outstanding pool of candidates recruited to the participating graduate programs in Pharmacology and Neuroscience and to the well-respected laboratories as post-doctoral fellows. We have an active outreach program designed to encourage participation of underrepresented minorities and fellows from disadvantaged backgrounds, including a NIDA-funded R25 postbaccalaureate program. We actively train our students and fellows in responsible conduct of research and ethical treatment of animal subjects. The program is proud of its 30-year history of success in training fellows who have gone on to very successful scientific careers.