ABSTRACT. The purpose of the UW ALACRITY Center is to address critical problems in the implementation of evidence-based psychosocial clinical interventions (CI) (e.g., psychotherapies) in nonspecialty service settings that are accessible to underserved communities (i.e., primary care clinics and schools). Use of CI is inhibited by longstanding problems with the usability, contextual fit, and engagement of both those CI and the implementation strategies (IS) (e.g., consultation models) the support them. This situation also results in high rates of “reactive adaptations” of CI/IS by their intended users in many settings where they are deployed. Building on our learnings and successes over the past 4 years, our interdisciplinary research team will draw from the fields of human- centered design (Drs. Munson, Fogarty), implementation science (Drs. Lyon, Bennett, Locke, Fortney, Bruns, van Draanen), psychosocial CIs (Drs. Areán, Raue, McCauley, Bearss, Walker), and research methods/data analysis (Drs. Pullmann, Dopp). The Center represents a unique partnership between the School of Medicine’s Departments of Psychiatry and Family Medicine, the Department of Human-Centered Design and Engineering, the Department of Computer Science, the School of Social Work, the School of Public Health, and the College of Education. The Center also bridges UW’s many resources: The Institute for Translational Health Sciences (the UW CTSA), the AIMS Center (UW implementation center for collaborative care), the SMART Center (UW implementation center for education sector services), the WWAMI-region Practice Research Network (WPRN, primary care practices in Washington, Wyoming, Alaska, Montana and Idaho), and the MHTTC Northwest School Mental Health Network (public school districts across Washington, Oregon, Alaska, Idaho). The Administrative Core (AC) will serve as the communication hub between Center cores and advisory boards; oversee the selection of pilot studies; and coordinate mentoring, evaluation, and dissemination. The Methods Core (MC) will provide research infrastructure to projects and support use of our Discover, Design/Build, Test (DDBT) framework to address CI/IS usability, engagement, and appropriateness in partnership with local stakeholders. The MC will also compile project data to update and refine our Typology of CI/IS Modification Targets and Library of Redesign Solutions for dissemination and assess costs of DDBT-driven redesign. Research projects will collect common outcome data to determine the impact of modifying CI/IS targets. The Signature R01 will test a DDBT-designed decision support tool for Problem Solving Treatment in a large network of primary care clinics. R34 #1 will create a novel IS to support delivery of evidence-based classroom supports for students on the autism spectrum. R34 #2 will modify a well-researched CI for youth trauma for use in education settings. R34 #3 will adapt an existing effective IS to enhance delivery of school mental...