# Clinical Ascertainment, Biospecimen Acquisition, Data Management and Analysis Research Core

> **NIH NIH U19** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $531,333

## Abstract

CORE B ABSTRACT - Clinical Ascertainment, Retention and Biospecimen Acquisition Research Core
 The purpose of this core is to develop and support the two human birth cohorts which serve as the
study populations to address fundamental questions about the role of respiratory syncytial virus (RSV) on
childhood respiratory morbidity and asthma through scientific projects that focus on interactive pathways of the
host and virus on asthma development (Project 1), and interventions that may modify immune and airway
epithelial cell development through which RSV may cause asthma (Project 2). This clinical ascertainment,
retention and biosample acquisition and management research core will serve to manage the two human study
populations: Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure (INSPIRE) and
Childhood Allergy and the Neonatal Environment (CANOE), and manage the resultant key biospecimens and
data. Data acquisition will include careful phenotyping, RSV exposure assessment, physiologic testing, nasal
airway epithelial cell (NAEC) collection, nasal brushings, blood and peripheral blood mononuclear cells
(PBMCs), and DNA for Projects 1 and 2.
 This core is centered around the rich infrastructure at Vanderbilt and surrounding engaged pediatric
and obstetrical clinics to conduct the clinical studies. This includes support for the recruitment, enrollment and
retention of the birth cohorts, longitudinal follow-up, and the laboratory components of the biosample collection
and processing. This core assembles a complementary research team of epidemiologists, virologists,
immunologists, geneticists, biostatisticians, and research personnel experienced in cohort retention, and
biospecimen acquisition and will provide the data and biospecimens to analytic Core C where data will be
processed and biostatistical analyses will be conducted. This core is structured as two aims with each
supporting one of the two cohorts. The first is to facilitate and oversee the longitudinal follow-up of the
established INSPIRE birth cohort, biospecimen collection, including NAECs for Projects 1 and 2. The second is
to facilitate and oversee recruitment, enrollment and longitudinal follow-up of the new CANOE birth cohort, and
biospecimen collection, including NAECs for Projects 1 and 2.

## Key facts

- **NIH application ID:** 10847478
- **Project number:** 5U19AI095227-15
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Tina V Hartert
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $531,333
- **Award type:** 5
- **Project period:** 2011-08-04 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10847478

## Citation

> US National Institutes of Health, RePORTER application 10847478, Clinical Ascertainment, Biospecimen Acquisition, Data Management and Analysis Research Core (5U19AI095227-15). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10847478. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*