Assuring that all older adults coping with complex care needs at home have access to high-quality health and social services and providing essential support to their caregivers are significant and growing societal challenges. Effective responses to these priorities require research-informed solutions, especially those designed to reduce systemic and structural inequities that disproportionately threaten the capacity of many older adults to remain at home. The recent “hospital at home” movement is further fueling the demand for science-based care models that address health needs and preferences, mitigate the impact of adverse social determinants of health, and support caregivers, especially throughout challenging health transitions (e.g., new diagnosis, change in functional status) and health care transitions (i.e., movement across health care providers or settings). The 12 core faculty responsible for the proposed renewal of the NINR-funded Individualized Care for At-Risk Older Adults—a T32 training program based at the NewCourtland Center for Transitions and Health at the University of Pennsylvania School of Nursing—are uniquely positioned to prepare four predoctoral and two postdoctoral nurse trainees, appointed annually, to conduct transdisciplinary research designed to address these societal priorities. Guided by both the National Institute on Minority Health and Health Disparities’ Research Framework and the Agency for Healthcare Research and Quality’s Multiple Chronic Conditions Research Network conceptual model, and with a focus on the transitional care needs of at-risk older adults living at home and those of their caregivers, trainees will be positioned to conceptualize, design, and conduct research aimed at advancing integrated care models that promote health equity. Trainees will gain the theoretical knowledge and methodological skills necessary to conduct rigorous and reproducible research guided by the highest ethical standards, within a team science framework; employ contemporary and emerging research designs and methodologies; and promote knowledge synthesis, dissemination, and implementation, with the ultimate goal of conducting science that informs health care practices and policies and highlights nurses’ unique contributions. The proposed training program benefits from considerable faculty expertise in aging, health equity, transitional care, ethics, home and community-based care, and research methods. Led by two prominent nurse scientists, the program has evolved to foster breadth and depth of conceptual and empirical knowledge related to health inequities and integrated care models for diverse groups of older adults and their caregivers. Enhanced training in research methods will emphasize sophisticated data science, emerging mixed methods designs, and multi- level interventions with enhanced translational potential. Since 2007, this T32 has prepared 23 predoctoral fellows and 24 postdoctoral fellows who are successfully pursu...