Prevention and control programs, guided by a rigorous evidence base, can accelerate progress toward reducing cancer incidence and mortality in the United States. The number of individuals affected by cancer continues to grow as the U.S. population ages, and disparities in cancer incidence and mortality persist by race/ethnicity, socioeconomic position, and geography. Reducing the impact of cancer requires increasingly complex, transdisciplinary, and team science approaches that consider the role of social and structural determinants of health. Accordingly, we need to grow a diverse cancer prevention and control research workforce who are adept at transdisciplinary and multidisciplinary team science. Our ongoing Transdisciplinary Training Program in Cancer Prevention and Control T32 aims to train postdoctoral scholars and expand pipeline of prevention and control investigators. Housed in the Division of Public Health Sciences in the Washington University School of Medicine, and Siteman Cancer Center, we are intentional in creating a community of trainees from different public health disciplines, including behavioral sciences and epidemiology. Our Program Mentors have robust research programs in cancer prevention and control, and represent multiple schools and departments across the university. Our training program includes structured elements such as individual development plans, mentored research, and required training in cancer prevention/control and health disparities. Trainees customize their other didactic training to meet individual needs and goals. Our innovative approach includes a transdisciplinary journal club and career development seminars. Over the course of our first two cycles of funding, we have demonstrated success in recruiting, retaining, and training a diverse group of successful researchers. Of 18 completed trainees, 15 remain in research related positions, 2 are in further training, and 1 is delivering clinical cancer care. More than half of trainees are women, and half come from backgrounds under-represented in medicine. Several trainees now have K awards (1 K99-R00, 3 K01s) and other early career or pilot awards. They are well on their way to R01 funding. Our process includes evaluation and adaptation of the program based on internal and external advisors and the ever-changing field of cancer prevention and control. With this renewal, we will enhance training in rigor and reproducibility, team science, and create pathways to early leadership for our trainees. We have formalized requirements for mentor training for mentors and trainees. We will continue to leverage institutional resources, ongoing NIH-funded research, and a close collaboration with the NCI-designated Siteman Cancer Center to sustain and improve our training and impact. Washington University School of Medicine and Siteman Cancer Center offer a rich environment for trainees, and our transdisciplinary training in cancer prevention and control is a unique resour...