# Biorepository & Tissue Analysis Shared Resource

> **NIH NIH P30** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $57,812

## Abstract

BIOREPOSITORY & TISSUE ANALYSIS (BTA) SHARED RESOURCE: SUMMARY
The Hollings Cancer Center (HCC) Biorepository & Tissue Analysis (BTA) Shared Resource (SR) provides
investigators with access to meticulously collected and annotated human specimens as well as advanced
human and animal tissue analyses that require state-of-the-art instrumentation and expertise. The shared
resource comprises several integrated services, including a biospecimen and data repository; customized and
readily available tissue microarrays; RNA and DNA extractions; research pathology services, including
histologic analysis of fixed, frozen, and stained tissues; and analysis/interpretation of experimental results.
Three general themes underlie BTA activities that position us to deliver on our three Specific Aims, which offer:
1) tissue and clinical data acquisition; 2) tissue microarrays and analysis, and 3) integrated pathology services.
Since 2013, BTA has collected more than 26,500 cancer-associated biospecimens from patients with solid
tumors and hematological malignancies, all of which are annotated and linked to clinical data. A notable
feature of BTA is its ability to tailor the accrual of specimens to meet the specific needs of HCC members.
Currently, more than 25% of BTA tissue donors are African American patients, who are typically
underrepresented in biorepositories and cancer research. During the current funding period, BTA supported
the research of 41 HCC members, resulting in 64 peer-reviewed publications. BTA has made impactful
contributions to advance cancer research at HCC, including identifying specimens from underserved patients
with Sea Island ancestry and using MALDI imaging to study protein glycosylation patterns in cancer. In addition
to serving a growing group of HCC members, BTA contributes to major national biorepository efforts, including
the NCI-funded Cooperative Human Tissue Network, and the DOD-funded multi-center NCORP Early Onset
Malignancies Initiative (EOMI). BTA has also contributed to the success of the U54 SC CADRE grant and the
construction of a fully functioning biorepository at South Carolina State University (SCSU). Under the
leadership of Steven L. Carroll, MD, PhD (CBI), an expert in the autosomal dominant tumor susceptibility
syndrome neurofibromatosis type 1, BTA has created an ethnically rich and diverse tumor tissue biorepository
that serves as an important scientific resource for HCC members interested in linking basic biology findings to
the prevention, clinical diagnosis, and treatment of human cancer.

## Key facts

- **NIH application ID:** 10847776
- **Project number:** 2P30CA138313-16
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **Principal Investigator:** Angela Jiyeon Yoon
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $57,812
- **Award type:** 2
- **Project period:** 2009-04-01 → 2029-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10847776

## Citation

> US National Institutes of Health, RePORTER application 10847776, Biorepository & Tissue Analysis Shared Resource (2P30CA138313-16). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10847776. Licensed CC0.

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