CORE A: ADMINISTRATIVE CORE: PROJECT SUMMARY/ABSTRACT The responsibilities of the Administrative Core include monitoring and planning of scientific activities, providing scientific direction for the P01, ensuring the scientific integrity of all research projects and the integration of all program components. The Administrative Core is managed by Co- Directors, Drs. Leandro Cerchietti and Christopher Flowers, who will preside over the scientific quality of the Epigenetic basis and therapeutic targeting of the unique lymphoma immunological niche P01 and ensure communication, cooperation, and integration between the different components of the P01 Program. The primary goal of this Core is to assure the successful oversight and coordination of all projects and cores, through expert guidance in fiscal management, centralized communication, and general administration for all activities. The Administrative Core will provide leadership and coordinate the activities of the Executive Committee (which consists of all Project Co-Leaders and Core Co- Directors), the External Advisory Board member and the Conflict Resolution Committee members. Specific responsibilities of the Administrative Core include: 1) to oversee all projects and cores, 2) to monitor the scientific integrity of all research projects, and grant awards, and assure compliance with institutional, governmental, and National Cancer Institute (NCI) regulations, 3) to monitor and oversee all fiscal and budgetary issues, 4) to convene all meetings of the P01 Executive Committee, and External Advisory Boards 5) to communicate with the NCI Program Officer and other NCI staff to prepare all required reports and publications, 6) to notify the NCI Program Officer promptly of important developments that affect the management of the P01 either positively or negatively, 7) to schedule and organize all necessary meetings, including monthly scientific meetings, lectures, symposia, and attendance at any NCI-sponsored meetings/workshops, 8) to develop and maintain of effective communication resources for all participants of the P01, 9) to achieve integration with institutional leadership and other institutional resources, including data management, 10) to ensure all P01 investigators have access to the various institutional cores supported by the WCM Hematologic Malignancy Program and the MD Anderson Department of Lymphoma and Myeloma and CCSG, and 11) to oversee the collaboration between the Lymphoma Model Systems (Core 1), Genomics, Epigenomics, Computational Biology and Biostatistics Core (Core 2), the Multiparameter Imaging and Pathology Core (Core 3), and the P01 Projects.