# The AD Knowledge Portal Data Coordination Center

> **NIH NIH U24** · SAGE BIONETWORKS · 2024 · $3,261,591

## Abstract

ABSTRACT
Alzheimer's disease (AD) is a complex neurodegenerative disorder affecting millions of Americans, yet
therapeutic options to prevent, slow, or cure AD and related dementias (ADRD) remain limited. The
multifactorial nature of AD/ADRD along with a heterogeneous presentation across individuals, necessitates
multiple therapeutic approaches. The National Institute on Aging (NIA) has established a series of research
programs to diversify the therapeutic pipeline, including the Accelerating Medicines Partnership in Alzheimer's
Disease Target Discovery and Preclinical Validation project (AMP-AD) and dozens of additional consortia and
projects. These programs employ open science practices to understand the molecular complexity of AD/ADRD
and identify new avenues for treatment. The Data Coordination Center (DCC), led by Sage Bionetworks,
supports these programs by overseeing dissemination of research outputs through the AD Knowledge Portal
and the Agora Platform. These platforms have been widely utilized, with thousands of researchers having
accessed data and hundreds of publications referencing their use. The DCC also promotes cross-project
integrative analyses through working groups, which have yielded significant contributions in terms of
harmonized datasets and cross-consortium publications. As the AD Knowledge Portal Data Coordination
Center, we will leverage and expand our existing processes, systems, and infrastructure to further our mission
to accelerate translational research in AD. We propose to: 1) apply Findable, Accessible, Interoperable,
Reusable (FAIR) practices to define data and metadata standards and oversee data contribution and
governance; 2) use evidence-based strategies to engage the consortium in collaborative cross-team research
projects; (3) disseminate consortium-generated resources through the AD Knowledge Portal and Agora and
develop interoperability with the broader ecosystem of AD/ADRD data and resources; and 4) maximize the
impact of AD Knowledge Portal resources on basic and translational AD/ADRD research through outreach and
engagement with the broader research community.

## Key facts

- **NIH application ID:** 10848073
- **Project number:** 2U24AG061340-06
- **Recipient organization:** SAGE BIONETWORKS
- **Principal Investigator:** Laura Michelle Heath
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $3,261,591
- **Award type:** 2
- **Project period:** 2018-09-30 → 2029-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10848073

## Citation

> US National Institutes of Health, RePORTER application 10848073, The AD Knowledge Portal Data Coordination Center (2U24AG061340-06). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/10848073. Licensed CC0.

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