SUMMARY The Administrative Core of the Center will provide the exchange of information, strategic planning and coordination of the Center, guide the selection and progress of collaborative projects (CPs) and service projects (SPs), monitor accomplishment of the aims for each component of the Center. The Core will also oversee the budget allocations and the development and utilization of resources, and oversee the dissemination and outreach. Overall, the Administrative Core will serve as a hub for coordination of the Center and all its components. The Administrative Board (PD/PI, leads and co-leads of all TR&Ds) will oversee the overall operation of the Center. They will be assisted by three staff members (Technical Coordinator, Research Engineer, Grants Manager) and three postdocs representing the trainees. Three specific aims will be pursued. Aim 1: Management of the Center’s activities. The Administrative Core will provide the financial support, logistics and oversight of each individual TRD, CP and SP, and foster synergistic interactions between the Center’s components towards accomplishing the Center’s mission. Aim 2: Management of Training, Dissemination and Outreach. The Administrative Core will plan and oversee the interactions within the Center and with external collaborators and users, dissemination of the Center’s results and capabilities to the academic, clinical and commercial sectors, and outreach to the community. Aim 3: Management of Technology Translation and Commercialization. The Administrative Core will oversee the CPs and SPs, and the translation and commercialization of the Center’s products and technologies.