# Clinical Science Research Core

> **NIH NIH P30** · WASHINGTON UNIVERSITY · 2024 · $316,393

## Abstract

PROJECT SUMMARY/ABSTRACT - CLINICAL SCIENCE RESEARCH CORE
The Clinical Science Research Core (CSRC) enhances and facilitates leading-edge clinical and translational
nutrition/obesity research through the operation of two distinct but interactive sub-cores that provide an array of
services and unique training through a cohesive, “one-stop” organizational structure that ensures optimal
integration of high-quality services and training.
The Clinical Studies Performance sub-core assists investigators by: i) providing consultation in designing a
clinical research study and in interpreting the results of the data generated by core analyses, ii) providing
biostatistical support to determine adequate sample size and appropriate statistical analysis, iii) measuring
body composition and energy expenditure, iv) developing and preparing study protocol-specific meals for
metabolic testing and take-out meals for diet intervention studies, v) preparing stable isotopically labeled
metabolic tracer and hormone infusates to assess metabolic function, vi) providing high-quality, clinical
laboratory tests used to determine participant eligibility, monitor participants during interventions, and evaluate
metabolic functions, vii) obtaining muscle and adipose tissue biopsy samples and inserting radial artery
catheters for blood sampling, viii) evaluating cardiovascular function, ix) performing exercise and physical
performance testing, x) providing inpatient and outpatient sleep monitoring services, xi) providing assistance in
implementing lifestyle interventions (diet manipulation, weight loss/weight gain, exercise training); and xii)
providing training in specific procedures to aid investigators in the performance of clinical studies.
The Metabolic Kinetics sub-core assists investigators by: i) providing consultation in designing protocols to
evaluate metabolic kinetics (e.g., the hyperinsulinemic-euglycemic clamp procedure and frequently sampled
intravenous glucose tolerance test in conjunction with stable isotopically-labeled tracer infusions to evaluate
whole-body and tissue- -cell function) and in interpreting the results of the data
generated by core analyses, ii) mass-spectrometry analysis of biospecimens to determine tracer enrichment in
metabolic substrates and macromolecules, iii) mathematical modeling of tracer and non-tracer data to assess
metabolic kinetics, and iv) providing education and training in specific analyses. The Metabolic Kinetics sub-
core has a long tradition of providing these services and in the past has focused its sample analysis and
modeling on specific metabolites to evaluate specific metabolic pathways (e.g., adipose tissue triglyceride
lipolytic rate, hepatic glucose production rate, VLDL-triglyceride and apolipoprotein B-100 production rate). The
core has now expanded these services to include the new and rapidly evolving discipline of dynamic
metabolomics, which makes it possible to evaluate metabolite flux through entire metabolic...

## Key facts

- **NIH application ID:** 10848320
- **Project number:** 5P30DK056341-24
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Bettina Mittendorfer
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $316,393
- **Award type:** 5
- **Project period:** 1999-09-30 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10848320

## Citation

> US National Institutes of Health, RePORTER application 10848320, Clinical Science Research Core (5P30DK056341-24). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10848320. Licensed CC0.

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