# Bioinformatics  and Data Integration Core

> **NIH NIH P01** · UNIVERSITY OF ROCHESTER · 2024 · $332,074

## Abstract

SUMMARY: In this Program Project, the bioinformatics core (Core C) will continue to provide computational
support. Core C will help process and analyze the large amount of data that will be generated by the four
projects. We propose a comparative study of genome maintenance and Alzheimer’s disease in relation to
longevity in mammals. While it has long been observed that mammals differ enormously in their lifespans, the
mechanisms behind this difference remain unclear. Lack of this information is an important problem, because,
without this knowledge, acquiring the ability to modulate aging on the whole organism level is highly unlikely.
Our long-term goal is to understand the mechanisms that determine longevity and susceptibility to Alzheimer’s
disease. The overall objective of the bioinformatics core is to provide computational support and service to the
project investigators – namely, both to work with each project to handle the data generated therein and to
integrate data from all projects to achieve the aims of the program project grant as a whole. The central
hypothesis of this Program Project is that long-lived mammals have evolved specific molecular mechanisms
that mediate their longevity. This hypothesis has been formulated on the basis of preliminary data produced in
the applicants' laboratories. The rationale for a dedicated bioinformatics core is that a consolidated facility is
needed to manage the large amount of data on the whole genome level generated by each of the four highly
integrated projects of this program project. This bioinformatics core will achieve two specific aims: 1) To assist
the four research projects with data processing and analysis and develop new, dedicated tools to be used by
PPG investigators; 2) To generate a high-quality bowhead whale genome assembly and annotation for this
Project and as a resource for the research community; and 3) To maintain and further develop the PPG
website, launch Degu Resource website to provide the community with novel Alzheimer’s disease model and
develop a high-speed data portal for internal and public data sharing. The function of the bioinformatics core is
significant, because it will be set up to meet the challenge posed by the high volume of data that needs to be
generated, examined at multiple levels by a variety of approaches, and integrated to develop the models of
lifespan control, and shared among project investigators.

## Key facts

- **NIH application ID:** 10848565
- **Project number:** 2P01AG047200-11
- **Recipient organization:** UNIVERSITY OF ROCHESTER
- **Principal Investigator:** Zhengdong Zhang
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $332,074
- **Award type:** 2
- **Project period:** 2014-05-01 → 2029-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10848565

## Citation

> US National Institutes of Health, RePORTER application 10848565, Bioinformatics  and Data Integration Core (2P01AG047200-11). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10848565. Licensed CC0.

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