Project Summary/Abstract The Pediatric Emergency Medicine Research Training Program (PEMRTP), established in 2001, offers a unique and comprehensive training experience for MD and PhD biomedical researchers focused on investigating acute illnesses and injuries in pediatric emergency medicine (PEM). With millions of children visiting emergency departments (EDs) annually, the need for evidence-based care and effective diagnostics and treatments is paramount. As pediatric research enters a new paradigm driven by data-driven care, artificial intelligence, genomics, and optimization of electronic health record systems, the PEMRTP aims to advance the care of acutely ill and injured children by training independent researchers, with a strong focus on informatics, genomics, and artificial intelligence. The COVID-19 pandemic also highlighted the central role of pediatric EDs in children's healthcare, and as a critical link in national public health surveillance programs. This competing renewal builds upon the assets of Boston Children's Hospital, housing the largest PEM faculty worldwide, to create a culture of rigorous research and training. The program's goals remain to prepare trainees for independent research in PEM and address the critical need for research mentors in the field. The next funding cycle plans to include 12 participating trainees. Trainees in the PEMRTP will progress through four interrelated phases, including mentored research projects, ongoing didactic instruction, formal coursework (optional), and preparation of a research grant. Additionally, trainees have the opportunity to pursue formal coursework for advanced degrees such as Master of Medical Science or Master of Public Health. Benefiting from the extensive research laboratories, clinical systems, academic programs, experienced faculty, and connections to multisite research networks at Boston Children's Hospital, the Computational Health Informatics Program, and the Department of Biomedical Informatics at Harvard Medical School, the PEMRTP provides an unparalleled environment for mentoring trainees to become future leaders in pediatric emergency medicine research.