PROJECT SUMMARY / ABSTRACT Roswell Park Comprehensive Cancer Center (Roswell Park) operates nine Cancer Center Support Grant (CCSG) shared resources and eight institutionally supported shared resources. All 17 shared resources are centrally managed through the Shared Resource Management Office (SRMO), a division of our Research Support Services Department. The mission of the SRMO is to provide exceptional service delivery within the shared resources to our members. All SRMO personnel are members of the CCSG administration team. The SRMO, CCSG Administration, and Shared Resource Advisory Committees (SRACs) oversee, guide, and support the Shared Resource Directors and appropriate Associate Directors in enabling access to advanced research technologies and technical capabilities for all CCSG members. During the project period, Roswell Park reconfigured the CCSG shared resources to facilitate stronger leadership, streamlined processes, and improved financial oversight. In consultation with the CCSG External Advisory Board, and each of the SRACs, the SRMO consolidated the services and leadership of 8 shared resources into 4 combined CCSG shared resources to strategically align better with the needs of our CCSG members. The SRMO facilitates consolidated/centralized billing, operational guidance, human resources support, equipment and service line management, and support for the marketing of services offered by the individual shared resources. The Specific Aims for Shared Resource Management are: AIM 1: To provide comprehensive oversight for Roswell Park shared resources, with the goal of effectively managing strategic alignment, operations, marketing, and training. AIM 2: To evaluate the need for new specialized technologies, services, and expertise that enhance scientific interactions and productivity. AIM 3: To engage with shared resource leaders and invest in service delivery and purchase of new equipment that leads to cost-effective, reliable, and quality-controlled processes. AIM 4: To establish policies for shared resource access, use, and financial management thereby ensuring appropriate services are available and cost effective for all CCSG members. The SRMO plans to continue to provide administrative, financial, and oversight management and exceptional support to our CCSG members. Roswell Park places a strong focus on advanced technologies to maintain our status as leaders in cancer research and patient care. In support of our strategic plan, the SRMO will continue to the support existing shared resources and facilitate the development of new shared resources and services in areas such as metabolomics, current good manufacturing practices (cGMP), community engagement, and software development.