PROGRAM SUMMARY / ABSTRACT Precision Environmental Health uses “omics” technologies and data science to understand how our environment influences human health and disease. The Training in Precision Environmental Health Sciences (TPEHS) Program is designed to give the next generation of environmental health scientists the training needed to advance their careers the field of Precision Environmental Health. TPEHS is a joint initiative of Baylor College of Medicine, University of Texas (UT) Health Science Center Schools of Public Health and Biomedical Informatics, and UT MD Anderson Cancer Center-the latter two new for this renewal, further expanding our Program. These premier research-intensive institutions in the Texas Medical Center, the world’s largest medical center, have joined together to address the need for a Precision Environmental Health workforce of tomorrow with training at the intersection of Genomics/epigenomics, Environmental Health, and Data Science (GxExD). TPEHS is at the vanguard of one of the leading environmental health sciences research communities in the country. Our Program leverages multi-disciplinary research being conducted in the NIEHS P30 Gulf Coast Center for Precision Environmental Health, P42 Superfund Research Center and NIMHD/NIEHS P50 Center of Excellence in Environmental Health Disparities. TPEHS Program Objectives are for trainees to 1) acquire fundamental knowledge in Genomics/epigenomics, Environmental Health, and Data Science; 2) become proficient at integrating concepts of GxExD into their research; and 3) gain the necessary skills and tools to leverage TPEHS training to achieve their career objectives. This T32 will provide stipends for 4 pre- and 3 post-doctoral trainees each year, matched by strong institutional commitments to support 4 additional pre- and post-doctoral trainees, expanding our cohort size and increasing TPEHS impact and diversity. The Core Curriculum for predoctoral trainees includes didactic coursework in Genetics/Epigenetics, Environmental Health/Toxicology, Data Science, Responsible Conduct of Research, and training in Rigor and Reproducibility. All TPEHS trainees take a required “Big Data Foundations” course and engage in structured Career Development activities and networking opportunities. TPEHS has 42 well-funded training faculty, experienced Program Director (PD) and Co-PDs representing all participating institutions, guided by Steering and External Advisory Committees and trainee feedback, with administrative support provided by the Gulf Coast Consortia. Our pool of applicants is robust and trainees diverse: 18% of T32-supported trainees are from underrepresented groups, over half women and include those who seek (or have) PhD, MD, MD/PhD and MD/MPH degrees. Our trainees have a strong cohort identity, and publish in both high-impact general interest and top-tier specialty environmental health journals. At the end of the program, all TPEHS trainees have a deep understanding of GxE...