# Core A: Biospecimen Repository and Pathology

> **NIH NIH P50** · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $209,143

## Abstract

CF1: Biospecimen Repository and Pathology Core
ABSTRACT
The Biospecimen Repository and Pathology Core (CF1) is designed to provide support to the basic and
translational research efforts of the SPORE. CF1 will play a central role in collecting, annotating, storing,
distributing, and tracking of tissue and blood biospecimens from patients enrolled in research protocols. The
Core will provide SPORE investigators with expert histopathological evaluation of tumor samples both from
patients enrolled on research protocols and from murine and xenograft models. Additionally it will assist in
selecting appropriate formalin-fixed, paraffin-embedded (FFPE) tissue and snap-frozen tissue for research and
pilot projects, as well as enable the creation of tissue microarrays (TMAs) for SPORE investigator studies. CF1
will assist in performing and interpreting immunohistochemical studies and fluorescence in situ hybridization
(FISH) assays. It will provide scanning and digital archiving of TMA images and reliable interpretation, scoring,
and archiving of IHC results from FFPE or TMA sections. CF1 will also provide systematic assessment of tumor
response to therapy in human tissues and in sarcoma murine models, including interpretation of
immunohistochemical markers for drug response, such as changes in kinase phosphorylation, proliferation
inhibition, and induction of apoptosis. It will also provide a centralized resource for mutational annotation of
sarcoma samples and cell lines using the MSK-IMPACT platform. Finally, CF1 ensures linkage of specimens to
the clinical sarcoma database (within CRDB) in collaboration with project leaders, the Biostatistics and
Bioinformatics Core (CF2 Qin/Socci) and the Administrative Core (Singer). This establishes a substantial
infrastructure and allows us to provide the required services in a cost-effective manner. CF1 is tightly integrated
with the MSK institutional Pathology Core (supported by the MSK Cancer Center Core Grant) and the sarcoma
clinical database managed by the Administrative Core.

## Key facts

- **NIH application ID:** 10848817
- **Project number:** 2P50CA217694-06A1
- **Recipient organization:** SLOAN-KETTERING INST CAN RESEARCH
- **Principal Investigator:** CRISTINA R ANTONESCU
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $209,143
- **Award type:** 2
- **Project period:** 2018-09-01 → 2029-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10848817

## Citation

> US National Institutes of Health, RePORTER application 10848817, Core A: Biospecimen Repository and Pathology (2P50CA217694-06A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10848817. Licensed CC0.

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