# Advanced Imaging and Computational Approaches

> **NIH NIH P01** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $215,663

## Abstract

The Advanced Microscopy and Computational Approaches Core (Core C) will provide advanced
imaging and computational approaches to support this Program Project in elucidating the
molecular mechanisms of DNA replication stress that drive therapeutic response and resistance
in SCLC. The microscopy approaches provided include multi-color STORM imaging, live-cell
single-molecule tracking, and time-lapse microscopy of cells and tumoroids using established
protocols and methods. Core C will establish automated data analysis pipelines for quantitative
analysis of microscopy, sequencing and mass spectrometry data generated by all the Projects,
and provide strategies for integration of the different data modalities. Core C will establish an
infrastructure for dissemination of data, results, and pipelines, and provide interactive
web-based user interfaces to allow the scientific community to easily explore the data generated
in the projects. Core C will also develop teaching material covering the microscopy and
computational approaches implemented.

## Key facts

- **NIH application ID:** 10848850
- **Project number:** 1P01CA288368-01
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** David Fenyo
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $215,663
- **Award type:** 1
- **Project period:** 2024-08-16 → 2029-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10848850

## Citation

> US National Institutes of Health, RePORTER application 10848850, Advanced Imaging and Computational Approaches (1P01CA288368-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10848850. Licensed CC0.

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