The overarching objective of the proposed program is to provide an enriched and innovative predoctoral training experience to foster the next generation of stellar neuroscientists. The Broad-based Research, Analytics, and Innovation in Neuroscience (B2RAIN) Predoctoral Training Program takes advantage of the University of Florida’s exceptional strength in neuroscience and its burgeoning Artificial Intelligence/data science communities. Given these strengths, the University of Florida (UF) is uniquely suited to offer a training program that strongly aligns with the stated goals of the Jointly Sponsored NIH Predoctoral Training Program in the Neurosciences and to offer the first such program to predoctoral trainees in the State of Florida. Indeed, UF offers an exceptional environment for the B2RAIN program that includes a strong cadre of dedicated and productive mentors. The B2RAIN program is carefully designed to integrate a well-rounded core neuroscience curriculum with coursework and practical experiences that will enable neuroscience predoctoral trainees to build strong quantitative skills that emphasize AI principles, coding, experimental design, and statistical rigor. Moreover, students will acquire a full complement of critical interdisciplinary skills around communication, collaboration, rigor, and resilience that will bolster individual scientific and professional success. The requested funds, together with a strong institutional commitment, will enable a minimum of eight neuroscience predoctoral students to enter the program annually and for these students to be fully supported during their initial two years of doctoral training while acquiring the essential foundational skills offered by the B2RAIN program. A minimum of forty doctoral neuroscience students will benefit from this training over the course of 5 years. Following the comprehensive training in fundamental neuroscience and rigorous quantitative approaches offered by the B2RAIN program, the students will be well-prepared to complete doctoral research with one of over forty outstanding preceptors. These mentors, who hail from across the UF campus, are dedicated to the training mission and offer a wealth of expertise across a wide range of neuroscience subdisciplines including systems/behavioral neuroscience, neurogenetics, cognitive neuroscience, and neurodegeneration. Trainees will be recruited from a talented cohort of applicants to the UF neuroscience Ph.D. program and will demonstrate the potential to become the next generation of innovators to drive progress in uncovering the complexities of the nervous system in both health and disease. The emphasis on quantitative skills, scientific rigor, and on acquiring essential professional skills important for long-term career success will add significant value to the participating students’ doctoral training experience. Specifically, the B2RAIN Training Program will equip trainees with the cross-disciplinary knowledge, skills, and p...