SHARED RESOURCE MANAGEMENT (SRM): PROJECT SUMMARY The overarching goal of the Georgetown Lombardi Comprehensive Cancer Center (LCCC) Shared Resource Management (SRM) is to ensure LCCC Members across the Consortium have access to cutting-edge technologies, exceptional staff, and quality services to enable high-impact cancer research and scientific interaction and productivity. The LCCC Shared Resources (SRs) are directed by Stephen Byers, PhD, Associate Director (AD) for SRs since 2005. In 2019, LCCC was awarded consortium status with the John Theurer Cancer Center (JTCC) of Hackensack Meridian Health (HMH) in New Jersey (NJ), and the SR activities broadened to serve investigators at both LCCC campuses. Byers is supported by two highly qualified SR Administrative Directors: David Goerlitz, MS (DC), and Steven Park, BS (NJ) to ensure that SRs meet LCCC Member needs. LCCC currently has nine SRs: Animal Models; Biostatistics & Bioinformatics; Flow Cytometry & Cell Sorting; Genomics & Epigenomics; Histopathology & Tissue; Mass Spectrometry & Analytical Pharmacology; Microscopy & Imaging; Survey, Recruitment, & Biospecimen Collection; and Tissue Culture & Biobanking. SRM oversees SR budgets and operations to ensure access, prioritization, and integration of state-of-the-art services and technologies across the Consortium. SRM carries out annual surveys to assess SR user satisfaction and gather suggestions regarding new services/instruments. Byers chairs the LCCC SR Oversight Committee, which meets quarterly and is comprised of Scientific Leaders and representative LCCC Members and provides recommendations regarding SR space, resources, policies, and procedures. Each SR has a specific SR Advisory Committee (SRAC) consisting of representative users and SR-specific experts from both LCCC campuses that meets at least annually to provide oversight of SR services, usage, user satisfaction, personnel, and finances. Byers actively participates in the LCCC Senior Leadership and Executive Committees to provide strategic input and ensure SR alignment with the Center’s programmatic research activities and priorities. During the current project cycle, SRM accomplishments include managing the acquisition and installation of new equipment ($12.3 million) and a biorepository LIMS system (OpenSpecimen), the introduction of NJ-based pharmacokinetics, pharmacodynamics and mass spectrometry imaging services to form the new MSAPSR, expansion of the zebrafish facility, an S10-supported small animal MRI, and the development of multiple Spatial Biology applications. SRs provided a broad range of services to all three LCCC Research Programs, supporting the cancer research activities of 90 LCCC Members, including 17 based in NJ, and directly contributing to 263 peer- reviewed publications, 50 of which appeared in high-impact journals (IF ≥ 10), and 225 peer-reviewed extramurally funded research grants.