# Histopathology & Tissue Shared Resource

> **NIH NIH P30** · GEORGETOWN UNIVERSITY · 2024 · $95,943

## Abstract

HISTOPATHOLOGY & TISSUE SHARED RESOURCE: PROJECT SUMMARY
The Histopathology & Tissue Shared Resource (HTSR) is the Georgetown Lombardi Comprehensive Cancer
Center (LCCC) resource for accessing human tissue for translational research and provides comprehensive,
high-quality laboratory and interpretive pathology services. The HTSR collects and distributes fresh, frozen, and
formalin-fixed, paraffin-embedded tissues and select biofluids from 15,440 patients; provides technical and
pathology support for investigator-driven collection protocols; and offers complementary services to LCCC
Members in DC and NJ. The facility is Co-Directed by Brent Harris, MD, PhD, who oversees services and
provides comprehensive pathology services in DC, and David Kar-Fai Chow, MD, who oversees Hackensack
Meridian Health’s (HMH) Biorepository (BioR) and provides comprehensive pathology services in NJ. The HTSR
facilitates discovery and innovative cancer research by collecting and distributing high-quality, clinically
annotated human tissue and liquid biospecimens for translational research projects across the Consortium. The
DC facility also provides comprehensive histology services including tissue processing, paraffin and frozen
section microtomy, staining, immunohistochemistry (including quantitative multiplex), immunofluorescence, as
well as tissue microarray (TMA) construction, staining and interpretative analysis. Research consenting and
specimen collection processes were revamped in NJ which has helped expand and diversify the biospecimen
resources available to LCCC Members. The DC and NJ facilities provide clinicopathologic expertise that
complements LCCC biomedical informatics services, clinical and pathology database search capabilities,
consultation services, and educational support and training for users. In response to user surveys, investigator
feedback, guidance from the HTSR Advisory Committee , and External Advisory Committee recommendations
since the last CCSG review, the HTSR expanded services to include quantitative automated brightfield and
immunofluorescence image analysis, immunophenotyping, miRNA in situ staining, enhanced tissue microarray
(TMA) construction, and newly acquired molecular platforms to support spatial biology applications (RNAscope,
Nanostring GeoMx, Akoya Phenocycler, and Standard Biotools IMC). The HTSR works cooperatively with the
Genomics & Epigenomics SR, Tissue Culture & Biobanking SR, Survey Recruitment & Biospecimen Collection
SR, and the Mass Spectrometry & Analytical Pharmacology SR to prepare human and animal model tissues and
cultures for downstream molecular analyses. In FY2022 the HTSR provided services to 37 LCCC Members
across all three Research Programs (15 Cancer Cell Biology Members, 20 Cancer Host Interactions Members,
and 2 Cancer Prevention and Control Members). In the current project period, HTSR’s impact is demonstrated
through support of 54 peer-reviewed publications, including 14 papers published in high-i...

## Key facts

- **NIH application ID:** 10849019
- **Project number:** 2P30CA051008-30
- **Recipient organization:** GEORGETOWN UNIVERSITY
- **Principal Investigator:** BRENT T HARRIS
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $95,943
- **Award type:** 2
- **Project period:** 1997-08-15 → 2029-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10849019

## Citation

> US National Institutes of Health, RePORTER application 10849019, Histopathology & Tissue Shared Resource (2P30CA051008-30). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10849019. Licensed CC0.

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