# Administrative Core

> **NIH NIH P01** · VIRGINIA COMMONWEALTH UNIVERSITY · 2024 · $113,020

## Abstract

CORE 1 – ADMINISTRATIVE CORE: SUMMARY
The overall goal of this P01 program project grant (PPG) application, titled ELEVATE, is to evaluate novel
therapeutic approaches for hepatocellular carcinoma (HCC) in pre-clinical models, with the ultimate objective
of transitioning these approaches to Phase I/II clinical trials. To achieve this, a team of investigators with robust
expertise in HCC, mouse modeling, cancer immunotherapy, nanoparticle-based delivery, and medicinal
chemistry will continue to collaborate on four highly integrated research projects. Core 2, the Mouse Model and
Pathological Analysis Core, will provide crucial support by generating essential mouse models to investigate
gene function and evaluate therapeutic responses. Additionally, Core 2 will provide critical analysis of tissue
samples to diagnose tumorigenesis and changes in response to treatment. Core 3, the Biostatistics and
Bioinformatics Core (BBC), will provide biostatistical and bioinformatics support across the projects. Given the
complex interactions among the four projects and two cores, the Administrative Core (Core 1) will provide
critical support to facilitate overall integration, planning, and management of the ELEVATE program. Core 1,
the Administrative Core, will 1) provide overall research direction and program oversight by setting the
research agenda focused on novel treatment approaches for HCC; 2) deliver general administrative and fiscal
management support, which will ensure effective and efficient intra- and inter-institutional communication,
coordination, and compliance with all terms and conditions of the grant; 3) promote communication and
integration within the program, facilitate constructive review and enhancement of the research progress
through frequent and deliberate interactions with expert External and Internal Scientific Advisory Committees
(ESAC and ISAC, respectively), and create and maintain a PPG website and secure portal for enhanced
communications and data sharing/dissemination by and among the research projects; and 4) facilitate and
promote collaborative science by organizing and coordinating annual retreats and symposia on HCC. Core 1
will ensure seamless collaboration among all components of the ELEVATE program to accomplish the overall
and specific project goals.

## Key facts

- **NIH application ID:** 10849087
- **Project number:** 1P01CA275740-01A1
- **Recipient organization:** VIRGINIA COMMONWEALTH UNIVERSITY
- **Principal Investigator:** Devanand Sarkar
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $113,020
- **Award type:** 1
- **Project period:** 2024-08-08 → 2029-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10849087

## Citation

> US National Institutes of Health, RePORTER application 10849087, Administrative Core (1P01CA275740-01A1). Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/grant/nih/10849087. Licensed CC0.

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