# Genetics and Genomics of Human Disease

> **NIH NIH T32** · YALE UNIVERSITY · 2024 · $369,802

## Abstract

Project Summary/Abstract
Continuing support is requested for years 46-50 of the Yale Predoctoral Training Program in Human Genetics
and Genomics. The program constitutes 52 trainers, the majority of whom are primary or secondary appointees
in the Department of Genetics at the School of Medicine. Virtually all of the trainees over the last funding period
have been matriculated in the Molecular Cell Biology, Genetics & Development Track (MCGD) in Biological and
Biomedical Sciences at Yale. The proposed training program is focused on the use of genetic, genomic and
computational approaches to understand human biology and disease. Training encompasses three core
domains: 1) The genetics of human health and disease, encompassing disease gene discovery and the
interpretation of human genetic variation; 2) Experimental studies in model organisms to understand how human
genetic variation influences human biology and disease; and 3) Genomic technologies and computational
approaches to obtain biological insights from complex genomic datasets, both in human and model systems.
Training faculty include investigators who are world leaders in each of these domains. This integrated training
environment provides trainees with broad exposure to genetics, genomics and computational biology, and a rich
training environment that prepares them for careers in science. Students admitted into the program have strong
scientific backgrounds and research experience with high academic achievement. First year students are
supported by Yale. Students are then supported by the training grant in years 2 and 3, and thereafter by funds
in Training Faculty laboratories until graduation. Training in the first year includes formal course work focused
on genetics, genomics and data analysis, as well as research rotations leading to selection of the thesis advisor
and laboratory. In the second year, students complete course work and take a qualifying exam in which they
must demonstrate mastery of genetics and defend a written research proposal. Subsequent years are devoted
to dissertation research, development of experimental and analytic skills, and skills in written and oral
presentation, leading to preparation and publication of the thesis work. In addition, students engage in supervised
teaching experiences. The students also participate in Departmental and new Program-specific activities,
including a Program Symposium and a Career Development Workshop. These activities provide students with
targeted mentoring and career development opportunities and will help them develop a professional network of
peers and senior colleagues that they can draw upon throughout their careers. Support is requested for 5 years
for 7 Ph.D. students per year. Trainees are highly successful in completing their Ph.D. thesis work, publishing
their work in high-impact journals, and the vast majority continue to contribute to science after leaving the
program.

## Key facts

- **NIH application ID:** 10849239
- **Project number:** 2T32HD007149-46
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** James P Noonan
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $369,802
- **Award type:** 2
- **Project period:** 1978-07-01 → 2029-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10849239

## Citation

> US National Institutes of Health, RePORTER application 10849239, Genetics and Genomics of Human Disease (2T32HD007149-46). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10849239. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*