# Bioinformatics and Biostatistics

> **NIH NIH P01** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $167,061

## Abstract

Cardiovascular diseases, including atherosclerosis, are a major cause of death globally. Lipid-lowering therapies
and interventions lower the risk of major adverse clinical events such as myocardial infarction, but significant
residual risk remains. The proposed Program, “Cellular and Molecular Mechanisms of Atherosclerosis,” seeks
to better understand this residual risk and investigate possible mechanisms and interventions that could further
lower cardiovascular risk. The Program focuses on mechanisms of atherosclerotic plaque stabilization and
destabilization, with a focus on macrophages and their functions. Core B, Bioinformatics and Biostatistics, will
provide state of the art, coordinated services to the Program as a whole, and thus help the Program achieve its
overall goals. These services include (A) bioinformatic analysis of single-cell RNA sequencing (scRNA-seq) data;
B) bioinformatic analysis of CITE-seq data; C) bioinformatic analysis of bulk RNA-seq data; and D) biostatistical
support for study design, power, and correlative analyses. All Projects will use Core B services equally. The use
of Core B will enable application of state of the art bioinformatic and biostatistical analyses in consistent,
integrated and coordinated analysis pipelines within and across all three Projects for maximum scientific
inference, translation and impact as well as highest standards of reproducibility and comparison among all
Projects of the PPG Program and for data resource sharing and dissemination.

## Key facts

- **NIH application ID:** 10849320
- **Project number:** 1P01HL172741-01
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Muredach P Reilly
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $167,061
- **Award type:** 1
- **Project period:** 2024-07-01 → 2029-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10849320

## Citation

> US National Institutes of Health, RePORTER application 10849320, Bioinformatics and Biostatistics (1P01HL172741-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10849320. Licensed CC0.

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