# Harnessing the power of pangenomics to strengthen SMSR operations and resources

> **NIH NIH P40** · JACKSON LABORATORY · 2024 · $299,431

## Abstract

PROJECT SUMMARY / ABSTRACT – Curation and Informatics Component
The proposed project aims to establish a bioinformatics component within the Special Mouse Strain Resource
(SMSR) program at The Jackson Laboratory by taking advantage of advances in genomic technologies for
resource development and operations. By developing a pangenome resource that incorporates diverse strain
chromosomal assemblies and variant sets, the SMSR will enhance its strain resources, improve genetic
quality control operations, and support the research community in their use of these strains for genetic
analysis of complex traits and disease modeling. The project will involve the implementation of computational
tools, data curation, and management approaches, as well as the creation of an interactive portal for users to
explore the pangenome and compare it to the human reference genome. Through these efforts, the SMSR will
expand its user base, and enhance its own operational and research capabilities, in alignment with the NIH
Strategic Plan for Data Science and data management policies.

## Key facts

- **NIH application ID:** 10849556
- **Project number:** 3P40OD011102-24S1
- **Recipient organization:** JACKSON LABORATORY
- **Principal Investigator:** LAURA G REINHOLDT
- **Activity code:** P40 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $299,431
- **Award type:** 3
- **Project period:** 2001-07-01 → 2026-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10849556

## Citation

> US National Institutes of Health, RePORTER application 10849556, Harnessing the power of pangenomics to strengthen SMSR operations and resources (3P40OD011102-24S1). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/10849556. Licensed CC0.

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