# Stereoselective Nickel-Catalyzed Coupling and Cascade Reactions

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $290,470

## Abstract

Project Summary/Abstract
This proposal outlines the development of new chemical methods for cross-coupling
reactions for formation of strained rings and in domino reactions. The objectives of this
project are to generate new strategies for stereoselective coupling reactions, including
stereospecific and stereoconvergent reactions. Reactions will be triggered such that
typically sluggish functional groups, including alkyl alcohol derivatives, will participate.
The development of these reactions will directly impact the development of new
pharmaceutical agents by providing new strategies for their preparation.

## Key facts

- **NIH application ID:** 10849672
- **Project number:** 5R01GM135603-04
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** Elizabeth Reinhardt Jarvo
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $290,470
- **Award type:** 5
- **Project period:** 2021-09-01 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10849672

## Citation

> US National Institutes of Health, RePORTER application 10849672, Stereoselective Nickel-Catalyzed Coupling and Cascade Reactions (5R01GM135603-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10849672. Licensed CC0.

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