ABSTRACT Dr. Elise Riley is a Professor in the Division of HIV, Infectious Diseases and Global Medicine at the University of California, San Francisco. Trained as an epidemiologist, she has mentored 57 postdoctoral fellows and early-career faculty throughout her career while simultaneously leading research focused on the health consequences of HIV and drug use. She is currently funded by NIDA to conduct a study regarding the influences of polydrug use, viral load and inflammation on small vessel disease in people living with HIV. Here she proposes an expansion of the parent study to include measures of tryptophan catabolism, which will provide a better understanding of cerebrovascular dysfunction through the consideration of multiple physiological pathways. Within this expanded investigation, Dr. Riley will continue growing and improving the content of her individual-level mentoring program. In parallel, she will partner with the UCSF Center for AIDS Research (CFAR) to create a new virtual mentoring module within the existing CFAR mentoring program. In combination, the proposed activities will provide multiple opportunities for training in patient-oriented research and career development for early career investigators.