# Clinical Laboratory Core (CLC)

> **NIH NIH P20** · BROWN UNIVERSITY · 2024 · $808,072

## Abstract

Abstract
 Substance use is associated with increased risk of, progression to, and negative outcomes from chronic
disease. Although associations between substance use and chronic disease are well documented, specific
mechanisms underlying these associations are poorly understood and underappreciated. There is a pressing
need for innovative, prospectively-designed, longitudinal studies that can clarify how biopsychosocial variables
contribute to linkages between substance use and chronic disease. However, coordinating and obtaining the
scientific expertise, clinical acumen, equipment, and other resources needed for these studies can be difficult
and time consuming, particularly for early-career scientists. Providing these resources through a research core
can enhance investigator productivity and promote scientific rigor and reproducibility. Thus, the overall aim of
the CADRE’s Clinical Laboratory Core (CLC) is to support research led by CADRE investigators, other
investigators at Brown University, and investigators from other IDeA-state institutions who are conducting
research on substance use and chronic disease, by identifying and providing the scientific expertise, clinical
acumen, technical capability, and other resources necessary to meet the needs of their projects. These
resources build on and complement, but do not overlap, resources currently available at Brown. Specific Aim 1
of the CLC is to provide the resources necessary for conducting both in-person and remote human subjects
research on substance use and chronic disease. Specific Aim 2 is to create a business plan that expands the
user base of the CLC, utilizes a fee-for-service model of cost recovery, and enables the CLC to be self-
sustaining when COBRE funding ends. Specific Aim 3, an exploratory aim, is to continue to build a center-wide
database of transdiagnostic risk factors associated with the development and progression of SUDs and chronic
disease. The successful achievement of these aims will be a thematically- and technically-linked center that
supports the initial and future projects, enhances the competitiveness of the project leaders for independent
external funding, becomes a national leader in understanding biobehavioral mechanisms linking SUDs and
chronic disease, and serves as a resource for training and research within Brown, regionally, and nationally.

## Key facts

- **NIH application ID:** 10849985
- **Project number:** 2P20GM130414-06
- **Recipient organization:** BROWN UNIVERSITY
- **Principal Investigator:** JENNIFER W. TIDEY
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $808,072
- **Award type:** 2
- **Project period:** 2019-08-01 → 2029-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10849985

## Citation

> US National Institutes of Health, RePORTER application 10849985, Clinical Laboratory Core (CLC) (2P20GM130414-06). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10849985. Licensed CC0.

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