# A Resource Center for Tetrahymena Thermophila

> **NIH NIH P40** · WASHINGTON UNIVERSITY · 2024 · $219,016

## Abstract

Curation and Informatics: Summary / Abstract
This proposal seeks continued funding for the Tetrahymena Stock Center to enable maintenance of the
Tetrahymena Stock Center and Tetrahymena Genome Database (TGD) together to create a comprehensive
resource providing both physical samples (e.g. cell line) and curated information, enabling a wide range of
scientific investigations. In this renewal application, we will implement several new innovations related to
resource curation to facilitate biological and biomedical research. A major goal of this work is to increase the
findability of physical resources by improving the interconnectivity between the two components of this
resource. We will also focus on evaluation of our operations and practices, information that we will review with
our external advisory committee, to ensure that we are most efficiently serving our research community. The
overall aims of our curation activities are to 1) improve curation of stocks by assigning RRID designations to
new acquisitions and use bioinformatics to link genes associated with specific stocks to human disease-
associated genes. In addition, we will post accurate DNA sequences of plasmid DNA resources. The goal is to
increase findability and usability of these physical resources; 2) increase the interoperability of genomic
data at TGD by updating the current gene annotations based on recent curation, expanding the quality and
quantity of Gene Ontology (GO) annotations, and adding links to gene annotations at common bioinformatics
data and protein feature resources; 3) consolidate and display gene expression data sets. We will develop
guidelines that will help researchers format and submit their expression data files to TGD so that they can be
placed in datahubs and displayed on the Tetrahymena genome browser or the WashU epigenome browser; 4)
increase the capacity of web portals to gather assessment data. Improvements to the Stock Center
website are planned that will allow us to monitor usage, improve transparency in the stock ordering process,
and capture user information and thereby allow the Stock Center to better serve the research community. By
improving these genome resources and assisting researchers with analysis pipelines, the Stock Center can
provide the highest level of support to the research community.

## Key facts

- **NIH application ID:** 10850070
- **Project number:** 2P40OD010964-20
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** DOUGLAS LEE CHALKER
- **Activity code:** P40 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $219,016
- **Award type:** 2
- **Project period:** 2004-04-01 → 2029-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10850070

## Citation

> US National Institutes of Health, RePORTER application 10850070, A Resource Center for Tetrahymena Thermophila (2P40OD010964-20). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10850070. Licensed CC0.

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