ABSTRACT This competing continuation application builds on nine successful five-year cycles of NRSA/NHLBI supported academic and applied research training in cardiovascular (CV) epidemiology at the Department of Epidemiology, University of North Carolina (UNC), Gillings School of Global Public Health. The program's goal is to train effective and independent researchers in the disciplines and methods intersecting CV epidemiology, in order to channel qualified scientists into a diversified workforce capable of addressing the national burden of CVD. Historical strengths of the program include excellence in training and mentoring, trainee productivity, successful transitions to careers in science, and the recruitment and support of trainees from groups underrepresented in the sciences. This program has actively pursued strategic innovation and ongoing improvements to better prepare population scientists and keep our program salient and effective. New elements to the be added in this continuation application include an external Distinguished Alumni Council, and expanded training and research opportunities in data and information science as an additional area of research emphasis. Of the 43 pre-doctoral and post-doctoral trainees completing their degree program or postdoctoral fellowships over the past 15 years, 27 (63%) currently hold faculty positions at major research universities. Overall, 40 (93%) of trainees over the last 15 years currently hold research positions in either academics, federal movement or private industry. The 15 trainees in the program during this cycle published 72 peer reviewed manuscripts, nearly half (49%) of which as first authors. Of the 15 individuals appointed in the current cycle, 4 are in groups underrepresented in biomedical sciences. Of the 10 trainees currently in the program, 3 are from underrepresented groups. The program's leadership and support structure include a program steering committee, an external advisory body of Distinguished Alumni, and trainee support teams. Distinctive features of the program are effective mentorship, career development planning, modular curriculum structure, on-going peer-led workshops, interdisciplinary seminar series, faculty and trainee-led journal club, research practica and breadth of research collaboration opportunities. The program enjoys strong institutional support. The program also conducts careful evaluation by the trainees and faculty of the effectiveness of the program and its productivity. As part of this application, we request funding for five predoctoral and three postdoctoral trainee positions.