# Mitochondrial Function and In Vivo Imaging Core

> **NIH NIH P30** · OCEAN STATE RESEARCH INSTITUTE, INC. · 2024 · $223,019

## Abstract

The Mitochondrial Function and In Vivo Imaging (MF-II) Core
The overall goal of the CardioPulmonary Vascular Biology (CPVB) COBRE program is to facilitate high impact
vascular biology research. The CPVB COBRE has successfully supported numerous innovative studies for a
better understanding of the pathogenesis and the associated mechanisms of cardiopulmonary diseases. Over
these years, there has been increasing interest and requests from the CPVB COBRE investigators and other
scientists to perform mitochondrial function assessments and high-resolution in vivo imaging in preclinical
studies. The Mitochondrial Function and In Vivo Imaging (MF-II) Core has evolved from the Respiratory Core
that was established in 2021 as the 2nd technical core of the CPVB COBRE based on user needs. The mission
of the MF-II Core is to develop a centralized system for mitochondrial function assessments and high-resolution
in vivo imaging, with the goals to enhance productivity, promote interdisciplinary and inter-institutional
collaborations, and increase research impact of the CPVB COBRE investigators and other investigators in the
state of Rhode Island. To date, the Respiratory/MF-II Core have served 30 unique users with 4,030 services.
There is a ~2.2-fold increase in yearly technical core services from the Phase I to the Phase II. In Phase III, the
overall objective of the MF-II Core is to facilitate the scientific objectives and technical repertoire of the CPVB
COBRE Pilot Project Investigators and other Rhode Island and IDeA investigators by providing centralized
cutting-edge technologies and essential services.
The specific aims of the MF-II Core are to: i) offer effective, reproducible, and economical services in high-
resolution in vivo imaging and mitochondria function assessments to pilot project investigators and the scientific
community; ii) acquire, establish, and disseminate technologies and instrument capabilities to provide state of
the art research tools for pilot project investigators and the scientific community; iii) facilitate interdisciplinary and
inter-institutional collaborations by providing technical services to enhance research productivity, and to foster
scientific networks by closely working with IDeA programs in Rhode Island and other states; iv) establish
processes and procedures that lead to sustainability of the MF-II Core. The MF-II Core will continue to provide
critical support to investigators in Phase III and beyond to augment and strengthen biomedical research
excellence in the state of Rhode Island and the other IDeA states.

## Key facts

- **NIH application ID:** 10850897
- **Project number:** 5P30GM149398-02
- **Recipient organization:** OCEAN STATE RESEARCH INSTITUTE, INC.
- **Principal Investigator:** Peng Zhang
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $223,019
- **Award type:** 5
- **Project period:** 2023-06-01 → 2028-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10850897

## Citation

> US National Institutes of Health, RePORTER application 10850897, Mitochondrial Function and In Vivo Imaging Core (5P30GM149398-02). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/10850897. Licensed CC0.

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