The Integrated Health Sciences Facility Core (IHSFC) facilitates multi-directional translational research between mechanistic, toxicological, clinical, and population-based studies to inform the scientific community, public health policy, and education. The IHSFC furthers the mission of the Southwest Environmental Health Sciences Center (SWEHSC) with a focus on the environmental exposures affecting human health that are unique to the diverse populations of the Southwest. The mission of the IHSFC stems from the three SWEHSC research themes: environmental exposures in underserved Southwest populations, environmental lung disease, and adaptive responses to environmental stressors, which span a number of environmental exposures including organic solvents, metals and metalloids, airborne particulate matter, and UV light exposure. To foster integrated environmental health research, the IHSFC is organized around three operational components. The Implementation Resource for Translational and Human Exposure Research provides strategic advice and resource support to SWEHSC investigators in sampling Southwest human populations and their living environment, communicating research findings with key stakeholders, and in helping investigators navigate translational research barriers. The Data Science Resource provides statistics, bioinformatics, database development and integration, and high-performance computing support and resources to investigators within a model of project partnership. The Inhalation Exposure Resource provides a vital new core facility to conduct inhalation exposure experiments in rodent and cellular models. By combining these three resource areas, the IHSFC provides integrated services and expertise in environmental exposure measurement and modeling, statistical modeling of the relationship between exposure and health outcomes, and mimicking real world exposures in experimental models of disease to understand their mechanistic underpinnings. IHSFC scientists work with investigators from all three SWEHSC research focus groups (RFGs) and Pilot Projects, serve as mentors for Career Development beneficiaries, and work with the Cellular Imaging and Omics Facility Cores to ensure consistent, professional statistics and bioinformatics study design, data management, and connectivity. Finally, the IHSFC collaborates extensively with the Community Engagement Core (CEC) to leverage established relationships with community stakeholders, identify exposures of concern to communities, assess environmental health literacy, and identify effective strategies for communicating research results and environmental risk to the people of Arizona and the Southwest.