# High-Throughput DNA Sequencing System

> **NIH NIH S10** · DANA-FARBER CANCER INST · 2024 · $1,035,125

## Abstract

Abstract: Project Summary
This grant proposal requests funding for a NovaSeq X Plus system manufactured by Illumina,
San Diego, CA. This instrument will be incorporated into a successful Genomics facility, the
Molecular Biology Core Facilities (MBCF) at the Dana-Farber Cancer Institute (DFCI). This core
facility has provided molecular biology services, both genomic and proteomic, by chargeback
since 1984. The NovaSeq X Plus will be used as a high impact expansion, complementary to
existing Next-Generation sequencing services currently provided by the MBCF on two Illumina
NextSeq 550s, 4 MiSeqs, a MiniSeq and a NovaSeq 6000. This expansion will allow cost
effective and rapid turnaround time for whole genome sequencing, whole genome methylation
profiling, single-cell genomics, and spatial transcriptomics applications. The increased capacity
and substantially less expensive cost per basepair will increase the economic feasibility of much
larger projects and improve access to cutting edge technology for smaller projects.

## Key facts

- **NIH application ID:** 10851325
- **Project number:** 1S10OD036228-01
- **Recipient organization:** DANA-FARBER CANCER INST
- **Principal Investigator:** Zachary T Herbert
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,035,125
- **Award type:** 1
- **Project period:** 2024-07-15 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10851325

## Citation

> US National Institutes of Health, RePORTER application 10851325, High-Throughput DNA Sequencing System (1S10OD036228-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10851325. Licensed CC0.

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