# Human Target Verification and Thymic Function Core

> **NIH NIH P01** · UNIVERSITY OF ARIZONA · 2024 · $175,496

## Abstract

CORE C- Abstract
The Human Target Verification and Thymic Function Core (Core C) was integrated into this program to
provide proof-of-concept verification, in human thymus, lymph node (LN), and T cell aging, of the targets and
pathways identified by the innovative approaches and mouse models of the research projects. Assets that
Core C brings to the program include the expertise of Core leaders who are widely acknowledged as world
experts in human thymus biology and aging and the Duke Human Vaccine Institute (DHVI) Human Thymus
Biobank that contains tissues and isolated cells from 890+ healthy human donors aged 1 day to 78 years, with
ongoing collection of new specimens. Core C also provides comprehensive histology, expert board-certified
pathology support, mouse and human sjTREC analysis and thymus gene expression profiling. Over the next
five years of the Program, Core C will continue to accelerate proof-of-concept verification of project-identified
mouse therapeutic targets/pathways in human thymus, LN, and T cell aging and independently monitor thymic
output, through two focused Service Tasks or Core Aims: 1) To define, characterize, and supply human tissue
panels from donors of defined age and sex to meet project-specific translation verification needs; and 2) To
provide central histologic and flow cytometric analyses on human thymus and obtain data from molecular
analyses on human and mouse thymus tissues. Use of Core C services in the renewal period is anticipated by
all three projects. Delivery of Core C services to Projects 1-3 is a key component of overall program synergy,
and very importantly, will provide critical proof-of-concept verification of applicability of mouse targets/pathways
to aging in human thymus. This will facilitate project goals for rejuvenation strategies to ameliorate age-
associated immune deficiencies and improve immune defense against infection and cancer as individuals age.

## Key facts

- **NIH application ID:** 10851681
- **Project number:** 5P01AG052359-07
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **Principal Investigator:** Laura P. Hale
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $175,496
- **Award type:** 5
- **Project period:** 2017-09-15 → 2028-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10851681

## Citation

> US National Institutes of Health, RePORTER application 10851681, Human Target Verification and Thymic Function Core (5P01AG052359-07). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10851681. Licensed CC0.

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