# Human Translation and Verification

> **NIH NIH P01** · UNIVERSITY OF ARIZONA · 2024 · $226,614

## Abstract

CORE D- Abstract
 Increased susceptibility to infectious disease is the most prominent consequence of aging of the immune
system. In addition to generating basic knowledge, Projects 1-3 of the “Thymic and peripheral aspects of T
cell aging and rejuvenation” Program Project (Program) will provide an array of potential rejuvenation
strategies. The Immunological Response & Rejuvenation Strategy Monitoring Core (Core D), located at the
University of Arizona, will provide the final experimental pipeline for testing those rejuvenation strategies.
Specifically, the global objective of Core D is to assess thymic export and peripheral maintenance of
naïve T cells following T cell rejuvenation in old mice, and determine whether such interventions can
improve adaptive and protective immunity against viral infection in old mice.
 The Core will provide dedicated personnel with the appropriate infectious disease expertise to ensure
consistency and quality control in the execution of study protocols, application of experimental procedures, and
animal observations and data collection necessary to meet the Program’s major research objectives. This
testing pipeline will not only separate candidate interventions by their efficacy, but will also identify potential
stages at which some rejuvenation strategies may fail to translate into improved immune function. Core D will
also combine treatments from different projects, as appropriate, to synergistically increase T cell production
and improve their maintenance in secondary lymphoid organs. The use of rigorous in vivo analysis to track
recent thymic emigrants, and immunity in response to West Nile virus, a pathogen that shows disproportionally
high morbidity and mortality within the elderly, will provide this Program and its Projects with stringent testing of
a full spectrum of peripheral immune functions and protective immunity following T cell rejuvenation in old
mice. Thereby, the Core will deliver rigorous preclinical data to enable translational rejuvenation efforts in
humans.

## Key facts

- **NIH application ID:** 10851683
- **Project number:** 5P01AG052359-07
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **Principal Investigator:** Jennifer L. Uhrlaub
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $226,614
- **Award type:** 5
- **Project period:** 2017-09-15 → 2028-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10851683

## Citation

> US National Institutes of Health, RePORTER application 10851683, Human Translation and Verification (5P01AG052359-07). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10851683. Licensed CC0.

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