# Smart, wearable artificial lung system

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $688,116

## Abstract

ABSTRACT
Tens of thousands of Americans with end stage lung disease (ESLD) are not candidates for lung transplant and
thus are doomed to suffer a long and miserable death from dyspnea, limitation of activity, and eventually total
respiratory failure. The long-term goal of this technology-development project is to improve the quality of life of
end stage lung disease (ELSD) patients by developing wearable artificial lungs that compensate for the changing
metabolic needs of the patient. The objectives of the current proposal are to: 1) develop the smart, wearable
artificial lung system; and, 2) evaluate the wearable artificial lung system in acute and chronic animal models. At
the completion of this project, we will have a functioning wearable artificial lung system that adjusts CO2
clearance based on patient needs, thereby enabling large changes in patient activity and disease status during
rehabilitation and daily life. We will be ready to perform extended animal tests and apply for an IDE for first in
human trials.

## Key facts

- **NIH application ID:** 10851690
- **Project number:** 5R01HL166186-02
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Joseph Allen Potkay
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $688,116
- **Award type:** 5
- **Project period:** 2023-06-01 → 2027-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10851690

## Citation

> US National Institutes of Health, RePORTER application 10851690, Smart, wearable artificial lung system (5R01HL166186-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10851690. Licensed CC0.

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