# Clinical Core

> **NIH NIH P01** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $1,212,154

## Abstract

Clinical Core Summary/Abstract
The Clinical Core of the Program Project Grant (PPG) has provided clinical, cognitive and
cognitive diagnostic adjudications, and coordinated autopsies for the past three cycles of the
PPG. For the 4th cycle of the PPG (PPG4), the Clinical Core continues this crucial responsibility
providing clinical and cognitive diagnostic classifications that are critical to the aims and
hypotheses of the Projects. The Clinical Core is primarily responsible for participant recruitment,
clinical evaluation and autopsy coordination. The Clinical Core will recruit 300 older adults over
the first two years and conduct annual clinical and cognitive assessments. Clinical assessments
include annual neuropsychological testing, medical history and neurological examination, and
assessments of function, behavior and mood, all of which will be used in the adjudication of
cognitive diagnostic classifications in support of Projects 1, 2, 3 and 4. Cognitive diagnoses are
adjudicated at biweekly diagnostic case conferences by a multi-disciplinary team from the
Clinical Core. The Clinical Core also conducts assessments of vascular risk (arterial stiffness,
carotid artery ultrasonography, and vascular endothelial function measures) and sleep (sleep
diary, actigraphy, and polysomnography) at baseline, and 24- and 48-months, in support of
Projects 1 and 2. The Clinical Core works with the Imaging Biomarker and Methodology Core
and the Fluid Biomarker and Methodology Core, providing participants and coordinating
scheduling and logistics for imaging and biofluid biomarker data to be obtained by these
respective Cores. The Clinical Core transfers all clinical, cognitive, behavioral, vascular and
sleep data to the Biostatistics and Data Management Core, and assists in merging these data
with the imaging and fluid biomarker data. Finally, building on prior experience in coordinating
autopsy cases, the Clinical Core confirms provisional autopsy intent and coordinates the
logistics for any new autopsy cases in support of Project 4.

## Key facts

- **NIH application ID:** 10851902
- **Project number:** 5P01AG025204-18
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** BETH SNITZ
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,212,154
- **Award type:** 5
- **Project period:** 2004-12-01 → 2028-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10851902

## Citation

> US National Institutes of Health, RePORTER application 10851902, Clinical Core (5P01AG025204-18). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10851902. Licensed CC0.

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