IBM Core Summary/Abstract Since 2005, the Imaging, Methodology, and Statistics (IMS) core described in earlier cycles of this PPG has provided projects with broad support for PET and MR image analyses, data management, and statistical expertise. Progress over the last 15 years has resulted in the evolution of a comprehensive data analysis infrastructure for PET and MR imaging studies in Alzheimer’s disease (AD) and related disorders at the University of Pittsburgh, supported by a large number of faculty and staff who have developed considerable technical expertise in the field of AD imaging. In this cycle (PPG4), the previous functions of the IMS core (PPG1-3) will be more efficiently divided across the Imaging Biomarkers and Methodologies (IBM) Core described here and the Biostatistics and Data Management (BDM) Core. The IBM Core will concentrate imaging resources and expertise to provide PPG4 projects and investigators with a broad range of imaging tools, methods, and technical expertise to support PET, high-field (3T) and ultra-high field (7T) MR imaging. The IBM Core will be responsible for the acquisition, analysis, and quality control of all PET and MR image data collected in support of PPG4 projects, and will maintain a direct interface with the BDM Core to facilitate the efficient transfer of raw and processed PET and MR images and imaging outcomes, which include PET indices of amyloid, tau, and astroglial pathologic burden, as well as 7T MR measures of cortical thickness, regional volumes, and cerebrovascular disease burden, to the BDM Core, which we will assist with tasks related to the interpretation and dissemination of images and image outcomes. The IBM Core will continue to hold weekly meetings with other PPG researchers to discuss PET and MR data acquisition, processing, analyses, and general methodology issues, as well as to identify and adequately resource opportunities to develop novel PET and 7T MR imaging methodologies with the potential to positively impact PPG4 research and the field more broadly. The IBM Core will also continue to provide training to students, post-doctoral fellows, and faculty in neuroimaging methods.