# Center for Quantitative Biology: A focus on "omics", from organisms to single cells

> **NIH NIH P20** · DARTMOUTH COLLEGE · 2024 · $2,461,600

## Abstract

Center for Quantitative Biology: A focus on "omics", from organisms to single cells
PROJECT SUMMARY
High-throughput single-cell, spatial, and immune-cell -omic profiling technologies provide a wealth of data to
interrogate basic biological processes, changes in cellular processes, and the molecular basis of disease. When
combined with genomic data science, these fields are opening new frontiers in biology. Phase 1 established the
Center for Quantitative Biology (CQB) with the goal to support and enhance NIH-funded quantitative biological
research at Dartmouth and to facilitate integration of single-cell -omic technologies with cutting-edge
computational methods. The success of the CQB in Phase 1 is highlighted by the graduation of four Research
Project Leaders (RPLs), the onboarding of four new RPLs, and the hiring of seven new tenure-track faculty in
CQB focus areas. The IDeA program investment in CQB RPLs and research cores returned >$60 million in total
external funding, leveraging NIH funds 5:1. Phase 2 will build on the successes of Phase 1 by mentoring the
next generation of CQB COBRE RPLs, continuing growth of research cores, and enabling scientists to engage
in cutting-edge scientific inquiry. The CQB will continue to draw upon faculty from Dartmouth’s Geisel School of
Medicine, the Thayer School of Engineering, Arts & Sciences, and Dartmouth Health. Through its emphasis on
next-generation data, the CQB will synergize genomic data science with ongoing experimental genomic
initiatives across campus, a goal accomplished via four specific areas: 1) Enhance the research competitiveness
of junior faculty in genomic data science and experimental genomics by providing a research environment that
supports and enhances their projects. 2) Expand the breadth and impact of research from NIH-funded
quantitative biologists at Dartmouth by: (a) continuing to recruit talented quantitative biology faculty; (b)
mentoring junior quantitative biologists; and (c) providing systems for translating single-cell dynamics to
applications in human disease. 3) Develop, maintain, and leverage key shared resources to support faculty in
the CQB, at Dartmouth, and in the IDeA community by growing the Single-Cell Genomics and Genomic Data
Science Cores. 4) Create synergistic interactions between the dry-lab computational scientist and traditional
experimental scientist to promote cross-talk, collaboration, and integrative analyses between the disciplines.
Dartmouth continues to make a substantial institutional commitment to the success and long-term sustainability
of the CQB, including the commitment to hiring five new tenure-track faculty. Institutional program enrichment
funds will support research infrastructure, scientific exchange, and a pilot project program to foster a vibrant
intellectual community, recruit new project leaders, and enhance the impact and funding competitiveness of all
CQB members. With experienced leadership, efficient administrative structures, ...

## Key facts

- **NIH application ID:** 10852726
- **Project number:** 2P20GM130454-06
- **Recipient organization:** DARTMOUTH COLLEGE
- **Principal Investigator:** MICHAEL L WHITFIELD
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $2,461,600
- **Award type:** 2
- **Project period:** 2019-08-01 → 2029-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10852726

## Citation

> US National Institutes of Health, RePORTER application 10852726, Center for Quantitative Biology: A focus on "omics", from organisms to single cells (2P20GM130454-06). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10852726. Licensed CC0.

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