# ACQUISITION OF A QTRAP 7500 HYBRID QQQ/LIT MASS SPECTROMETER FOR PEDIATRIC TRANSLATIONAL RESEARCH

> **NIH NIH S10** · BAYLOR COLLEGE OF MEDICINE · 2024 · $597,985

## Abstract

ABSTRACT
The ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) system
consisting of a SCIEX QTRAP® 7500 MS System and Shimadzu Nexera Series 40 UHPLC system, contained
in this proposal, represents the most innovative LC/MS-based instrumental platform for small-molecule
quantitative bioanalysis on the market. At present, NIH-funded PIs working across a number of Texas Children’s
Hospital (TCH) Departments are increasing their application of quantitative mass spectrometry (MS)-based
bioanalysis in support of their translational research programs in pediatric medicine. These Departments include
Pediatrics-Gastroenterology, Hepatology, and Nutrition; Nephrology; Cardiology; Obstetrics and Gynecology;
and, Laboratory Medicine. Currently, the Texas Children’s Microbiome Center (TCMC) is the only TCH-based
facility, in the entire Texas Medical Center (TMC) campus that possesses UHPLC-MS/MS instrumentation and
expertise. The TCMC – Metabolomics and Proteomics Mass Spectrometry Laboratory (TCMC-MPMSL) has
witnessed steady growth in sample volume from 2020 to 2023, and our single UHPLC-MS/MS system is currently
analyzing ~9,000 samples per annum while consuming ~90% of the available instrument capacity. The reasons
for our funding request are two-fold: 1) expand our bioanalytical capacity to support the increasing levels of
pediatric-based translational research being performed at TCH; and, 2) upgrade our instrumental capabilities to
drive new biomedically-relevant discovery in support of pediatric patient care at TCH. Altogether, the instrument
included in this proposal will provide much needed capacity and new capabilities that the TCMC-MPMSL can
leverage to advance the basic and clinical research efforts of NIH-funded investigators at TCH in pediatric
medicine.

## Key facts

- **NIH application ID:** 10853915
- **Project number:** 1S10OD036416-01
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** Thomas Donald Horvath
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $597,985
- **Award type:** 1
- **Project period:** 2024-09-01 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10853915

## Citation

> US National Institutes of Health, RePORTER application 10853915, ACQUISITION OF A QTRAP 7500 HYBRID QQQ/LIT MASS SPECTROMETER FOR PEDIATRIC TRANSLATIONAL RESEARCH (1S10OD036416-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10853915. Licensed CC0.

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