Corrected Abstract Text The goal of this proposal is to address NIAID’s mission through continued implementation of a Genomic Center for Infectious Diseases, a collaborative program utilizing cutting-edge genomic technologies, including laboratory-based methods, bioinformatics processes and computational analyses. To ensure we achieve this, we have established an Administrative (Admin) Core with proven expertise managing a large-scale genomics program to combat a variety of existing and emerging infectious diseases, with the power and flexibility to support national and global public health priorities. The Administrative Core will be responsible for establishing, monitoring and reporting on individual Research Projects and Cores, as well as for budgetary oversight, and ensure progress across the entire center. The Admin Core will manage priorities, timelines and milestones, and ensure rapid public data release and dissemination of resources, including implementation of our Data Management and Sharing Plan. The Admin Core will manage our interactions with NIAID staff and other activities needed to maintain efficient and cooperative work among multiple centers. The Admin Core will manage and report on our Emergency Response Project Plan, as well as manage, track, and report on our relationships and collaborative work with the other GCIDs. Our Admin Core leadership, including PIs Neafsey and Birren, has extensive experience managing highly collaborative research, technology development, dissemination, and training in service of the wider infectious disease community and public health, and the variety of complex interactions that underlie these. The Specific Aims of this Core are as follows: Aim 1. Establish a Leadership Team, Organizational Structure and Management Practices to support a leading Genomics Center for Infectious Diseases. Our leadership and management plan will employ best practices from industry to establish clear goals and manage the center and its resources toward these goals. Aim 2. Establish an Outreach Program to ensure our center broadens participation in infectious disease research by supporting specialized workshops, hosting visits from collaborating trainees and scientists, and supporting research and training experiences of undergraduates. Aim 3. Organize and manage activities to enable rapid emergency responses to outbreaks and epidemics as well as synergistic, collaborative interactions among GCIDs. By establishing and actively managing the proper metrics for all aspects of our performance, utilizing professional management practices to maintain effective communication, and relentlessly improving our processes, the Admin Core will ensure we meet our initial goals and that we remain responsive to arising needs in serving NIAID’s mission combating infectious disease.