# Direct and Indirect Neurogenesis in the Mammalian Neocortex

> **NIH NIH R01** · CHILDREN'S RESEARCH INSTITUTE · 2024 · $693,662

## Abstract

ABSTRACT
The neocortex is the most complex cellular system in the natural world, the seat of motor, sensory and
executive function. While many of the mechanisms responsible for neocortical formation have been
discovered, key aspects of how neural precursor cells produce the exceptional variety of cortical neurons are
unknown. Recent advances in genomic analysis and in vivo cellular labeling enable study of cortical
development at an unprecedented level of resolution. Here we propose to operationalize our ability to label and
track specific lineages of neurons, based on whether they were produced directly or indirectly from the apical
radial glia stem cells, to determine how lineage information is used to construct the proper circuits in the
developing neocortex. These studies will use emerging evidence and new tools to elucidate how neural
precursor lineages influence neocortical growth.

## Key facts

- **NIH application ID:** 10854247
- **Project number:** 1R01NS136246-01
- **Recipient organization:** CHILDREN'S RESEARCH INSTITUTE
- **Principal Investigator:** Tarik F Haydar
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $693,662
- **Award type:** 1
- **Project period:** 2024-05-01 → 2024-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10854247

## Citation

> US National Institutes of Health, RePORTER application 10854247, Direct and Indirect Neurogenesis in the Mammalian Neocortex (1R01NS136246-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10854247. Licensed CC0.

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