# Promethion metabolic phenotyping system

> **NIH NIH S10** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $521,639

## Abstract

Project Summary/Abstract
We are proposing to purchase a new indirect calorimetry system, Promethion-Core metabolic phenotyping
system, which is a robust and versatile platform for researcher groups who are working towards gaining a
greater understanding of molecular mechanisms controlling energy balance and body weight regulation. It is
the most sophisticated and sensitive instrument in the market that simultaneously quantify multiple parameters
including oxygen consumption, carbon dioxide production, energy expenditure, substrate utilization, food and
water intake, and spontaneous activity. The new Promethion-Core system would provide sixteen individual
home cages at a time, that can do a continuous sampling of all parameters to ensure accuracy and scientific
rigor. A chamber for modulating the environment, including humidity, barometric pressure, temperature, light,
occupancy, and sound is also included. This would provide a marked upgrade over the existing system in our
UofU-MPC (the University of Utah Metabolic Phenotyping Core).
It will be extensively used by more than 18 NIH-funded research groups in UofU to capture synchronized
metabolic and behavioral information which can generate valuable insights into the understanding of molecular
pathways important in the regulation of energy balance and behavior.

## Key facts

- **NIH application ID:** 10854352
- **Project number:** 1S10OD036388-01
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** Ying Li
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $521,639
- **Award type:** 1
- **Project period:** 2024-05-15 → 2025-05-14

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10854352

## Citation

> US National Institutes of Health, RePORTER application 10854352, Promethion metabolic phenotyping system (1S10OD036388-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10854352. Licensed CC0.

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