# Integrated system for PET radiotracer synthesis

> **NIH NIH S10** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $375,665

## Abstract

PROJECT SUMMARY/ABSTRACT
The goal of this proposal is to install an integrated radiosynthesis system for the production of non-commercially
available PET radiotracers for preclinical imaging applications at the UC Davis Center for Molecular and Genomic
Imaging (CMGI). We propose to incorporate a commercial radiosynthesis unit dedicated to the production of
PET radiotracers complete with shielding enclosures allowing the safe and efficient production of the
radiotracers. The integrated system will allow for the automated production of PET radiotracers radiolabeled with
the positron emitter fluorine-18. It includes all necessary components to support radiotracer production and will
allow us to synthesize both established and novel PET radiotracers. As the NIH roadmap calls for an emphasis
on translational research and has identified molecular imaging as a priority, UC Davis is proposing to strengthen
functional and molecular imaging in animal models for future translation to humans by utilizing the system. The
system will be installed at the CMGI, which is a campus-designated and supported core facility providing
infrastructure and expertise to conduct in vivo imaging studies in animal models, from rodents to non-human
primates and companion animals. CMGI is the only location on our campus that oversees a cyclotron and
radiochemistry facilities dedicated to preclinical imaging research. Institutional support provided to the CMGI
ensures the successful operation and maintenance of the system for its lifetime. The system will support at least
10 major and minor users who are conducting NIH-funded research in diverse areas such as gene therapy,
neurology, oncology, toxicology, metabolic disorders, nanotechnology and biomedical engineering.

## Key facts

- **NIH application ID:** 10854579
- **Project number:** 1S10OD036374-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** JULIE L SUTCLIFFE
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $375,665
- **Award type:** 1
- **Project period:** 2024-07-15 → 2026-07-14

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10854579

## Citation

> US National Institutes of Health, RePORTER application 10854579, Integrated system for PET radiotracer synthesis (1S10OD036374-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10854579. Licensed CC0.

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