# A direct-indirect dual-layer flat-panel detector for breast cancer detection

> **NIH NIH R01** · STATE UNIVERSITY NEW YORK STONY BROOK · 2024 · $572,103

## Abstract

Project Abstract
The goal of the proposed work is to develop a novel dual-layer flat-panel detector (DLFPD)
based on mature energy-integrating detector technology and translate it clinically for dual-
energy spectral digital breast tomosynthesis (DE-DBT). This will improve the outcome of breast
cancer screening, diagnosis and treatment monitoring. Our objectives are two folds: 1. Develop
a DLFPD to allow rapid clinical translation of spectral breast imaging without patient motion
artifact. 2. Develop spectral imaging techniques based on DLFPD and establish its clinical
feasibility using patient studies. Our objectives will be accomplished through the following three
specific aims: (1) Design, optimize and fabricate a prototype DLFPD for spectral breast imaging.
Aim 1 will lead to the development and clinical translation of DLFPD that acquires two
mammograms at different energies using a single exposure, allowing perfectly registered
spectral images without artifacts due to patient motion. (2) Develop DLFPD based DE-DBT
techniques using simulation methods. Aim 2 will lead to the development of spectral image
processing techniques for DLFPD based systems with and without iodinated contrast agent. (3)
Integrate the prototype DLFPD with a clinical DBT system and investigate DE-DBT performance
through phantom and patient imaging studies. Aim 3 will translate the DLFPD and DE-DBT
techniques developed in Aims 1 and 2 into clinical reality. The outcomes of the proposed work
are: 1. Advancement in DLFPD hardware that permit rapid clinical translation; 2. Development
of a variety of DLFPD based DE-DBT techniques, with and without iodinated contrast agent; 3.
Clinical evaluation of the feasibility of DE-DBT for breast cancer detection.

## Key facts

- **NIH application ID:** 10856373
- **Project number:** 1R01EB035551-01
- **Recipient organization:** STATE UNIVERSITY NEW YORK STONY BROOK
- **Principal Investigator:** Wei Zhao
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $572,103
- **Award type:** 1
- **Project period:** 2024-06-01 → 2028-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10856373

## Citation

> US National Institutes of Health, RePORTER application 10856373, A direct-indirect dual-layer flat-panel detector for breast cancer detection (1R01EB035551-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10856373. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*